Geranylgeraniol Application in Human Osteoblasts and Osteoclasts for Reversal of the Effect of Bisphosphonates

Nitrogen-containing bisphosphonates lead to the depletion of geranylgeranyl pyrophosphate involved in the mevalonate pathway.The effect of geranylgeraniol (GGOH) on human osteoblast and osteoclast activities suppressed by zoledronate was investigated in this study.The effect of GGOH on human osteoblasts and osteoclasts subjected to treatment with z

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Re-description of Daphnia (Ctenodaphnia) from lakes in the Khumbu Region, Nepalese Himalayas, with the erection of a new species, Daphnia himalaya, and a note on an intersex individual

We present here a detailed description of Ctenodaphnia-type Daphnia specimens collected from lakes in the Nepalese Himalayas between 1994 and 2004, Cases including mature females and adult males.The specimens examined share certain diagnostic traits with Daphnia tibetana (Sars 1903), and others with Daphnia fusca (Gurney 1906).A re-appraisal of the

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